Smarties 2

Unique Components of Human Milk

Overview:

Human milk is a heterogeneous fluid that contains numerous nutritional and bioactive components. In the past, we identified protein, lactose, sodium and citrate in human milk as the biomarkers for the stage of lactation as well as pathologies such as mastitis. In addition, we have used fat content in human milk combined with infant test weighing to establish the fullness of the lactating breast and thereby estimate the volume of milk contained within the breast. The use of milk components as biomarkers provides a non-invasive and objective measure to understand milk synthesis, milk removal and supports the exploration of the health of both the breast and milk. Building our knowledge in this area will allow the development of evidence-based interventions that have a greater chance of improving both maternal and infant health on a global scale. Our research group is continuously seeking to standardise, redefine and develop analytical methodologies not only to discover new components of human milk but also to advance the scientific accuracy and precision of human milk analysis.

 

Projects


Trace metals and synthetic contaminants in human milk

Although the majority of milk components are synthesized in the lactocyte, trace metals and synthetic contaminants are likely transferred into milk via the maternal bloodstream. These components have the potential to greatly influence the growth and development of infants. This study is aimed at determining the levels of trace metals and synthetic contaminants in a historical cohort of milk samples collected from lactating mothers in Perth, WA, over the past 10 years. This project will explore the influences of rapid growth of the local population and dramatic changes in nutrition and lifestyle over the past 10 years on these milk components.

 


Human milk linguistics – decoding messages from mother to child

Human milk is an optimal nutrition for a growing infant which contains multiple bioactive components and factors that regulate infant growth and development, including appetite hormones, growth and inflammatory factors. We have limited knowledge about how these molecules relate to development of infant appetite control and lean and fat body mass (body composition), and how human milk and breastfeeding protect infants from developing obesity and obesity related health issues later in life.

This study will explore relationships of human milk bioactive components, such as insulin, glucose, leptin, active ghrelin, adiponectin, resistin, obestatin and cytokines including TNF-a and TGF-b with breastfed infants’ health, growth and development of body composition over 12 months of life and beyond, using new techniques (ultrasound and bioelectrical impedance spectroscopy). Additionally, the effect of maternal factors, such as adiposity, diet, health status on human milk composition will be elucidated, to further understand the influence mother has on her growing infant during lactation period.

Zoya Diagram


Microbiome of human milk

Beside macro and micro components, human milk has its own microbiome. However the formation of its microbiome and its influence on the colonization of the infant’s gut is only beginning to be understood. Therefore the study is aimed to characterise the microbiome of human milk and determine its stability and variability throughout lactation.